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Article

Impact of host cell line choice on glycan profile

20 Dec 2017

Abstract excerpt

Protein glycosylation is post-translational modification (PTM) which is important for pharmacokinetics and immunogenicity of recombinant glycoprotein therapeutics. As a result of variations in monosaccharide composition, glycosidic linkages and glycan branching, glycosylation introduces considerable complexity and heterogeneity to therapeutics. The host cell line used to produce the glycoprotein has a strong...

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PMID: 29262720
DOI: 10.1080/07388551.2017.1416577

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