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Article

CHO glycosylation mutants as potential host cells to produce therapeutic proteins with enhanced efficacy.

Advances in biochemical engineering/biotechnology - 1 Jan 2013

Zhang Peiqing, Chan Kah Fai, Haryadi Ryan, Bardor Muriel, Song Zhiwei

Abstract excerpt

CHO glycosylation mutants, pioneered by Stanley and co-workers, have proven to be valuable tools in glycobiology and biopharmaceutical research. Here we aim to provide a summary of our efforts to isolate industrially applicable CHO glycosylation mutants, termed CHO-gmt cells, using cytotoxic lectins and zinc-finger nuclease technology. The genetic defects in the glycosylation machinery in these cells lead to the...

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PMID: 23142953
DOI: 10.1007/10_2012_163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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