Article

LRP10 promotes trafficking of progranulin and prosaposin to lysosomes

2025-05-03

Abstract excerpt

Mutations in LRP10, a low-density lipoprotein receptor family member, cause familial Parkinson’s disease and dementia with Lewy bodies. However, its direct cellular functions remain largely undefined. Using a multidisciplinary approach, our new data shows that LRP10 is required for the efficient trafficking of progranulin and prosaposin to lysosomes. Loss of LRP10 resulted in aberrant Golgi accumulations of progra...

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Literature Corpus work: ec4eec9d-178e-57dc-b2f8-d1f250417850
DOI: 10.1101/2025.05.02.651888

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