Article
LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson's disease and dementia with Lewy bodies.
Acta neuropathologica - 1 Jul 2021
Grochowska Martyna M, Carreras Mascaro Ana, Boumeester Valerie, Natale Domenico, Breedveld Guido J, Geut Hanneke, van Cappellen Wiggert A, Boon Agnita J W, Kievit Anneke J A, Sammler Esther, Parchi Piero, Cortelli Pietro, Alessi Dario R, van de Berg Wilma D J, Bonifati Vincenzo, Mandemakers Wim
Abstract excerpt
Loss-of-function variants in the low-density lipoprotein receptor-related protein 10 (LRP10) gene have been associated with autosomal-dominant Parkinson's disease (PD), PD dementia, and dementia with Lewy bodies (DLB). Moreover, LRP10 variants have been found in individuals diagnosed with progressive supranuclear palsy and amyotrophic lateral sclerosis. Despite this genetic evidence, little is known about the...
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