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Article

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.

The Journal of cell biology - 14 Sept 2015

Zhou Xiaolai, Sun Lirong, Bastos de Oliveira Francisco, Qi Xiaoyang, Brown William J, Smolka Marcus B, Sun Ying, Hu Fenghua

Abstract excerpt

Mutations in the progranulin (PGRN) gene have been linked to two distinct neurodegenerative diseases, frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL). Accumulating evidence suggests a critical role of PGRN in lysosomes. However, how PGRN is trafficked to lysosomes is still not clear. Here we report a novel pathway for lysosomal delivery of PGRN. We found that prosaposin (PSAP)...

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Share to Adaptor Proteins, Vesicular Transport
Share to Low Density Lipoprotein Receptor-Related Protein-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26370502
DOI: 10.1083/jcb.201502029
PMCID: PMC4576858

Genes

PSAP
NCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.PMID 26370502Read ↗

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Lysosomal Dysfunction and Other Pathomechanisms in FTLD: Evidence from Progranulin Genetics and Biology.Semantic proximity Read ↗

C-Terminus of Progranulin Interacts with the Beta-Propeller Region of Sortilin to Regulate Progranulin TraffickingSemantic proximity Read ↗

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