Article
The lysosomal function of progranulin, a guardian against neurodegeneration.
Acta neuropathologica - 1 Jul 2018
Paushter Daniel H, Du Huan, Feng Tuancheng, Hu Fenghua
Abstract excerpt
Progranulin (PGRN), encoded by the GRN gene in humans, is a secreted growth factor implicated in a multitude of processes ranging from regulation of inflammation to wound healing and tumorigenesis. The clinical importance of PGRN became especially evident in 2006, when heterozygous mutations in the GRN gene, resulting in haploinsufficiency, were found to be one of the main causes of frontotemporal lobar...
Topics
- Animals
- Humans
- Lysosomes
- Models, Biological
- Mutation
- Neurodegenerative Diseases
- Progranulins
- Protein Transport