Article

Loss of Progranulin Results in Increased Pan-Cathepsin Activity and Reduced LAMP1 Lysosomal Protein

2023-07-16

Abstract excerpt

Mutations in the progranulin (PGRN) encoding gene, GRN , cause familial frontotemporal dementia (FTD) and neuronal ceroid lipofuscinosis (NCL) and PGRN is also implicated in Parkinson’s disease (PD). These mutations result in decreased PGRN expression. PGRN is highly expressed in peripheral immune cells and microglia and regulates cell growth, survival, repair, and inflammation. When PGRN is lost, the lysosome be...

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Literature Corpus work: 30f9d313-d402-5b4a-978c-59456cb1cd1d
DOI: 10.1101/2023.07.15.549151

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