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Article

The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress.

Cell reports - 7 Jul 2020

Kobiita Ahmad, Godbersen Svenja, Araldi Elisa, Ghoshdastider Umesh, Schmid Marc W, Spinas Giatgen, Moch Holger, Stoffel Markus

Abstract excerpt

The ability of pancreatic β-cells to respond to increased demands for insulin during metabolic stress critically depends on proper ribosome homeostasis and function. Excessive and long-lasting stimulation of insulin secretion can elicit endoplasmic reticulum (ER) stress, unfolded protein response, and β-cell apoptosis. Here we show that the diabetes susceptibility gene JAZF1 is a key transcriptional regulator of...

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Identifiers

PMID: 32640216
DOI: 10.1016/j.celrep.2020.107846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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