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Article

Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B.

Nature cell biology - 8 Jan 2012

Woo Connie W, Kutzler Lydia, Kimball Scot R, Tabas Ira

Abstract excerpt

Activation of Toll-like receptors (TLRs) induces the endoplasmic reticulum (ER) unfolded protein response (UPR) to accommodate essential protein translation. However, despite increased levels of phosphorylated eIF2α (p-eIF2α), a TLR-TRIF-dependent pathway assures that the cells avoid CHOP induction, apoptosis and translational suppression of critical proteins. As p-eIF2α decreases the functional interaction of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22231169
DOI: 10.1038/ncb2408
PMCID: PMC3271190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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