Back to search

Article

The stress-induced protein NUPR1 orchestrates protein translation during ER-stress by interacting with eIF2α

2020-02-19

Abstract excerpt

NUPR1 is a stress response protein overexpressed upon cell injury in virtually all organs including the exocrine pancreas. Despite NUPR1’s well established role in the response to cell stress, the molecular and structural machineries triggered by NUPR1 activation remain largely unknown. In this study, we uncover an important role for NUPR1 in participating in the unfolded protein response pathway and the endoplasm...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
529f5133-aa0e-5ed9-b9b0-44366840b97b
DOI
10.1101/2020.02.18.954115
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The stress-induced protein NUPR1 orchestrates protein translation during ER-stress by interacting with eIF2αDOI 10.1101/2020.02.18.954115
NUPR1 and its potential role in cancer and pathological conditions (Review)Semantic proximity
A new role for IFRD1 in regulation of ER stress in bladder epithelial homeostasisSemantic proximity
The UPRosome – decoding novel biological outputs of IRE1α functionSemantic proximity
Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and DiseaseSemantic proximity
Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survivalSemantic proximity
QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasisSemantic proximity
Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating KrasG12D-induced senescenceSemantic proximity
The Unfolded Protein Response in Secretory Cell FunctionSemantic proximity
NUPR1 is a critical repressor of ferroptosisSemantic proximity
Unfolded proteins in the mitochondria activate HRI and shut-down of mitochondrial protein translationSemantic proximity
Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulumSemantic proximity
NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and suppresses PDAC initiationSemantic proximity
Select a neighboring publication to make it the new centre.