Article

Modeling prediction error improves power of transcriptome-wide association studies

2017-02-14

Abstract excerpt

1 Transcriptome-wide association studies (TWAS) test for associations between imputed gene expression levels and phenotypes in GWAS cohorts using models of transcriptional regulation learned from reference transcriptomes. However, current methods for TWAS only use point estimates of imputed expression and ignore uncertainty in the prediction. We develop a novel two-stage Bayesian regression method which incorporat...

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Literature Corpus work: ec43d123-4e15-5286-a456-568579d6a1b2
DOI: 10.1101/108316

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