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Article

TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits.

American journal of human genetics - 1 Aug 2019

Nagpal Sini, Meng Xiaoran, Epstein Michael P, Tsoi Lam C, Patrick Matthew, Gibson Greg, De Jager Philip L, Bennett David A, Wingo Aliza P, Wingo Thomas S, Yang Jingjing

Abstract excerpt

The transcriptome-wide association studies (TWASs) that test for association between the study trait and the imputed gene expression levels from cis-acting expression quantitative trait loci (cis-eQTL) genotypes have successfully enhanced the discovery of genetic risk loci for complex traits. By using the gene expression imputation models fitted from reference datasets that have both genetic and transcriptomic...

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Identifiers

PMID: 31230719
DOI: 10.1016/j.ajhg.2019.05.018
PMCID: PMC6698804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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