Article

TP53 Mutations as Drivers of Chordoma Progression and Hallmarks of Aggressive Chordoma

2025-09-25

Abstract excerpt

<title>Abstract</title> <p>Introduction: Dedifferentiated (DC) and poorly differentiated chordomas (PDC) are rare, aggressive chordomas with a significantly worse prognosis than conventional chordomas (CC). The molecular mechanisms, driving them, remain poorly understood. <h4>Methods:</h4> Matched primary CC and recurrent DC cryopreserved samples from one patient were analyzed with whole-exome sequencing (WES). T...

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Literature Corpus work: ec3d1edb-dd63-5948-ac40-d11367c73ab5
DOI: 10.21203/rs.3.rs-7374485/v1

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