Article
TP53 mutations as drivers of chordoma progression and hallmarks of aggressive chordoma.
Acta neuropathologica communications - 19 Dec 2025
Baluszek Szymon, Kober Paulina, Wa̧grodzki Michał, Kunicki Jacek, Wojtaś Bartosz, Szadkowska Paulina, Kamińska Bożena, Passeri Thibault, Mandat Tomasz, Bujko Mateusz
Abstract excerpt
INTRODUCTION: Dedifferentiated (DC) and poorly differentiated chordomas (PDC) are rare, aggressive chordomas with a significantly worse prognosis than conventional chordomas (CC). The molecular mechanisms driving them remain poorly understood. METHODS: Matched primary CC and recurrent DC cryopreserved samples from one patient were analyzed with whole-exome sequencing (WES). Samples from three additional DCs and...
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