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Article

Mutational analysis of primary and advanced chordoma tissue using next‐generation sequencing

13 Aug 2025

Abstract excerpt

BACKGROUND: Chordomas are rare ectodermal bone malignancies derived from transformed notochordal remnants. Histologic variants include conventional (80%-90%), chondroid (5%-15%), and dedifferentiated (2%-8%). Because chordomas are relatively resistant to chemotherapy and radiotherapy, novel targeted agents are needed to expand treatment approaches and improve outcomes. This study analyzes the genomic landscape of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40802536
DOI: 10.1002/cncr.70033

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