A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling.

doi:10.1038/s41422-020-0355-0

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Article

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling.

Cell research - 1 Sept 2020

Qian Junbin, Olbrecht Siel, Boeckx Bram, Vos Hanne, Laoui Damya, Etlioglu Emre, Wauters Els, Pomella Valentina, Verbandt Sara, Busschaert Pieter, Bassez Ayse, Franken Amelie, Bempt Marlies Vanden, Xiong Jieyi, Weynand Birgit, van Herck Yannick, Antoranz Asier, Bosisio Francesca Maria, Thienpont Bernard, Floris Giuseppe, Vergote Ignace, Smeets Ann, Tejpar Sabine, Lambrechts Diether

Abstract excerpt

The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells, which are profoundly moulded by cancer cells. An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs. Here, we profile 233,591 single cells from patients with lung, colorectal, ovary and breast cancer (n = 36) and...

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PMID: 32561858
DOI: 10.1038/s41422-020-0355-0
PMCID: PMC7608385

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