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Article

GBA1 inactivation in oligodendrocytes affects myelination and induces neurodegenerative hallmarks and lipid dyshomeostasis in mice.

Molecular neurodegeneration - 7 Mar 2024

Gregorio Ilaria, Russo Loris, Torretta Enrica, Barbacini Pietro, Contarini Gabriella, Pacinelli Giada, Bizzotto Dario, Moriggi Manuela, Braghetta Paola, Papaleo Francesco, Gelfi Cecilia, Moro Enrico, Cescon Matilde

Abstract excerpt

BACKGROUND: Mutations in the β-glucocerebrosidase (GBA1) gene do cause the lysosomal storage Gaucher disease (GD) and are among the most frequent genetic risk factors for Parkinson's disease (PD). So far, studies on both neuronopathic GD and PD primarily focused on neuronal manifestations, besides the evaluation of microglial and astrocyte implication. White matter alterations were described in the central...

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Identifiers

PMID: 38454456
DOI: 10.1186/s13024-024-00713-z
PMCID: PMC10921719

Genes

GBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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