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Article

Glucocerebrosidase deficiency in dopaminergic neurons induces microglial activation without neurodegeneration

16 May 2017

Abstract excerpt

Mutations in the GBA1 gene encoding the lysosomal enzyme glucocerebrosidase (GBA1) are important risk factors for Parkinson's disease (PD). In vitro, altered GBA1 activity promotes alpha-synuclein accumulation whereas elevated levels of alpha-synuclein compromise GBA1 function, thus supporting a pathogenic mechanism in PD. However, the mechanisms by which GBA1 deficiency is linked to increased risk of PD remain...

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Share to Adenosine and Purinergic Signaling
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PMID: 28520872
DOI: 10.1093/hmg/ddx120

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