Article
Lysosome and Inflammatory Defects in GBA1-Mutant Astrocytes Are Normalized by LRRK2 Inhibition.
Movement disorders : official journal of the Movement Disorder Society - 1 May 2020
Sanyal Anwesha, DeAndrade Mark P, Novis Hailey S, Lin Steven, Chang Jianjun, Lengacher Nathalie, Tomlinson Julianna J, Tansey Malú G, LaVoie Matthew J
Abstract excerpt
BACKGROUND: Autosomal recessive mutations in the glucocerebrosidase gene, Beta-glucocerebrosidase 1 (GBA1), cause the lysosomal storage disorder Gaucher's disease. Heterozygous carriers of most GBA1 mutations have dramatically increased Parkinson's disease (PD) risk, but the mechanisms and cells affected remain unknown. Glucocerebrosidase expression is relatively enriched in astrocytes, yet the impact of its...
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