Article

A Novel Bispecific Antibody Targeting Frizzled7 and PD-L1 Reverses Immunotherapy Resistance in Non-Small Cell Lung Cancer by Reprogramming the Tumor Microenvironment

2026-04-29

Abstract excerpt

<title>Abstract</title> <p> Immunotherapy efficacy in non-small cell lung cancer (NSCLC) remains limited, largely due to aberrant activation of the Wnt/β-Catenin pathway. However, the precise role of its receptor Frizzled7 (Fzd7) in immune checkpoint inhibitor (ICI)-resistance remains unexplored. Here, we elucidate the role of Fzd7 in shaping the immunosuppressive tumor microenvironment (TME) and develop a novel...

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Literature Corpus work: 61eadd3f-7d7e-5172-b691-bdb1bfd95812
DOI: 10.21203/rs.3.rs-9337927/v1

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