Article
Mutations in the IFNγ-JAK-STAT Pathway Causing Resistance to Immune Checkpoint Inhibitors in Melanoma Increase Sensitivity to Oncolytic Virus Treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2021
Nguyen Tan-Trieu, Ramsay LeeAnn, Ahanfeshar-Adams Mozhdeh, Lajoie Mathieu, Schadendorf Dirk, Alain Tommy, Watson Ian R
Abstract excerpt
PURPOSE: Next-generation sequencing studies and CRISPR-Cas9 screens have established mutations in the IFNγ-JAK-STAT pathway as an immune checkpoint inhibitor (ICI) resistance mechanism in a subset of patients with melanoma. We hypothesized ICI resistance mutations in the IFNγ pathway would simultaneously render melanomas susceptible to oncolytic virus (OV) therapy. EXPERIMENTAL DESIGN: Cytotoxicity experiments...
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