Article

The c-Cbl-mediated non-canonical TGFBR2 neddylation drives BRAF V600E melanoma metastasis

2026-08-06

Abstract excerpt

<title>Abstract</title> <p> Background Metastatic dissemination is the main cause of death in patients with cutaneous melanoma, particularly those with the BRAF <sup>V600E</sup> subtype, in whom therapeutic resistance often limits durable disease control. Aberrant neddylation has been implicated in cancer progression. However, the contribution of non-canonical neddylation to melanoma metastasis remains poorly...

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Literature Corpus work: 77ef3e3f-4162-5bf0-9996-f0e6798253ca
DOI: 10.21203/rs.3.rs-10484027/v1

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