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Article

High-grade serous carcinomas arise in the mouse oviduct via defects linked to the human disease.

The Journal of pathology - 1 Sept 2017

Zhai Yali, Wu Rong, Kuick Rork, Sessine Michael S, Schulman Stephanie, Green Megan, Fearon Eric R, Cho Kathleen R

Abstract excerpt

Recent studies have suggested that the most common and lethal type of 'ovarian' cancer, i.e. high-grade serous carcinoma (HGSC), usually arises from epithelium on the fallopian tube fimbriae, and not from the ovarian surface epithelium. We have developed Ovgp1-iCreERT2 mice in which the Ovgp1 promoter controls expression of tamoxifen-regulated Cre recombinase in oviductal epithelium - the murine equivalent of...

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Identifiers

PMID: 28608929
DOI: 10.1002/path.4927
PMCID: PMC5568969

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