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Precious GEMMs: emergence of faithful models for ovarian cancer research

1 Mar 2018

Abstract excerpt

The development of Genetically Engineered Mouse Models (GEMMs) has catalyzed tremendous progress in cancer research. However, it has been difficult to design adequate mouse models for high-grade serous carcinoma (HGSC), the most common and lethal form of ovarian cancer. The genetic complexity of the disease, as well as the recent appreciation that most HGSCs arise from the fallopian tube (FT) secretory epithelium...

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PMID: 29493783
DOI: 10.1002/path.5065

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