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Article

Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis.

Arthritis research & therapy - 10 Feb 2024

Kim Daeun, Song Jaeseung, Mancuso Nicholas, Mangul Serghei, Jung Junghyun, Jang Wonhee

Abstract excerpt

BACKGROUND: Juvenile idiopathic arthritis (JIA) is one of the most prevalent rheumatic disorders in children and is classified as an autoimmune disease (AID). While a robust genetic contribution to JIA etiology has been established, the exact pathogenesis remains unclear. METHODS: To prioritize biologically interpretable susceptibility genes and proteins for JIA, we conducted transcriptome-wide and proteome-wide...

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PMID: 38336809
DOI: 10.1186/s13075-024-03280-2
PMCID: PMC10858498

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