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Antigen-driven PD-1 <sup>+</sup> <i>TOX</i> <sup>+</sup> <i>EOMES</i> <sup>+</sup> and PD-1 <sup>+</sup> <i>TOX</i> <sup>+</sup> <i>BHLHE40</i> <sup>+</sup> synovial T lymphocytes regulate chronic inflammation <i>in situ</i>

2019-12-28

Abstract excerpt

<h4>Introduction/Abstract</h4> T lymphocytes accumulate in inflamed tissues of patients with chronic inflammatory diseases (CIDs) and express pro-inflammatory cytokines upon re-stimulation in vitro 1–29 . Further, a significant genetic linkage to MHC genes suggests that T lymphocytes play an important role in the pathogenesis of CIDs including juvenile idiopathic arthritis (JIA) 30–33 . However, the functions o...

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Literature Corpus work
a0799379-6cfb-5ae8-9952-0a0168b2aef4
DOI
10.1101/2019.12.27.884098
Open publication

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Antigen-driven PD-1 <sup>+</sup> <i>TOX</i> <sup>+</sup> <i>EOMES</i> <sup>+</sup> and PD-1 <sup>+</sup> <i>TOX</i> <sup>+</sup> <i>BHLHE40</i> <sup>+</sup> synovial T lymphocytes regulate chronic inflammation <i>in situ</i>DOI 10.1101/2019.12.27.884098
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