Article

Coordinated immune dysregulation in Juvenile Dermatomyositis revealed by single-cell genomics

2023-11-10

Abstract excerpt

Juvenile Dermatomyositis (JDM) is one of several childhood-onset autoimmune disorders characterized by a type I interferon response and autoantibodies. Treatment options are limited due to incomplete understanding of how the disease emerges from dysregulated cell states across the immune system. We therefore investigated the blood of JDM patients at different stages of disease activity using single-cell transcript...

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Literature Corpus work: 46790d55-0ae3-543b-a9da-cd7dd3a5975d
DOI: 10.1101/2023.11.07.566033

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