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Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC

26 Feb 2025

Abstract excerpt

BACKGROUND AND AIMS: Recent advances in single-cell RNA sequencing (scRNA-seq) technologies have enabled us to clarify gene regulatory networks and immune cell compositions. In this study, the integration of large-scale bulk and single-cell datasets refined HCC classification and shed light on the characteristics of its aggressive subtype. APPROACH AND RESULTS: Single-cell analysis of 228,564 live cells from 6...

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PMID: 40009602
DOI: 10.1097/hep.0000000000001284

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