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Article

Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer

1 Oct 2019

Abstract excerpt

Cellular diversity in tumors is a key factor for therapeutic failures and lethal outcomes of solid malignancies. Here, we determined the single-cell transcriptomic landscape of liver cancer biospecimens from 19 patients. We found varying degrees of heterogeneity in malignant cells within and between tumors and diverse landscapes of tumor microenvironment (TME). Strikingly, tumors with higher transcriptomic...

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PMID: 31588021
DOI: 10.1016/j.ccell.2019.08.007

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