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Octapeptin C4 Induces Less Resistance and Novel Mutations in an Epidemic Carbapenemase-producing <i>Klebsiella pneumoniae</i> ST258 Clinical Isolate Compared to Polymyxins

2018-04-28

Abstract excerpt

<h4>ABSTRACT</h4> Polymyxin B and E (colistin) have been pivotal in the treatment of extensively drug-resistant (XDR) Gram-negative bacterial infections, with increasing use over the past decade. Unfortunately, resistance to these antibiotics is rapidly emerging. The structurally-related octapeptin C4 (OctC4) has shown significant potency against XDR bacteria, including against polymyxin-resistant (Pmx-R) strains...

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Literature Corpus work
ebce27e2-ad57-57e3-b888-8e96f8a9053d
DOI
10.1101/309674
Open publication

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Octapeptin C4 Induces Less Resistance and Novel Mutations in an Epidemic Carbapenemase-producing <i>Klebsiella pneumoniae</i> ST258 Clinical Isolate Compared to PolymyxinsDOI 10.1101/309674
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