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Article

Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae.

Microbial genomics - 1 Mar 2018

Pitt Miranda E, Elliott Alysha G, Cao Minh Duc, Ganesamoorthy Devika, Karaiskos Ilias, Giamarellou Helen, Abboud Cely S, Blaskovich Mark A T, Cooper Matthew A, Coin Lachlan J M

Abstract excerpt

Extensively drug-resistant Klebsiella pneumoniae (XDR-KP) infections cause high mortality and are disseminating globally. Identifying the genetic basis underpinning resistance allows for rapid diagnosis and treatment. XDR isolates sourced from Greece and Brazil, including 19 polymyxin-resistant and five polymyxin-susceptible strains, were subjected to whole genome sequencing. Seventeen of the 19...

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Identifiers

PMID: 29431605
DOI: 10.1099/mgen.0.000158
PMCID: PMC5885010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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