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Polymyxins and Bacterial Membranes: A Review of Antibacterial Activity and Mechanisms of Resistance

8 Aug 2020

Abstract excerpt

Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic development pipeline, together with the rising global prevalence of infections caused by multidrug-resistant (MDR) Gram-negative bacteria have both rejuvenated clinical interest in these polypeptide antibiotics. Parallel to the...

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PMID: 32784516
DOI: 10.3390/membranes10080181

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