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A Review of Resistance to Polymyxins and Evolving Mobile Colistin Resistance Gene (mcr) among Pathogens of Clinical Significance

6 Nov 2023

Abstract excerpt

The global rise in antibiotic resistance in bacteria poses a major challenge in treating infectious diseases. Polymyxins (e.g., polymyxin B and colistin) are last-resort antibiotics against resistant Gram-negative bacteria, but the effectiveness of polymyxins is decreasing due to widespread resistance among clinical isolates. The aim of this literature review was to decipher the evolving mechanisms of resistance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37998799
DOI: 10.3390/antibiotics12111597

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