Article

Understanding Recent Developments in Colistin Resistance: Mechanisms, Clinical Implications, and Future Perspectives

2025-04-10

Abstract excerpt

Colistin resistance, driven by chromosomal mutations and the spread of plasmid-mediated MCR genes, has emerged as a critical challenge in combating multidrug-resistant gram-negative bacteria. This resistance compromises the efficacy of colistin, leading to higher treatment failure rates, prolonged hospitalizations, and increased mortality. Recent studies highlight key mechanisms, including lipid A modifications, t...

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Literature Corpus work: 1fefaf36-7315-520b-be37-48f902824821
DOI: 10.20944/preprints202504.0901.v1

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