Article
Aberrant splicing of CHEK1 is a driver of megakaryocytic dysplasia in U2AF1S34F mutant myelodysplastic neoplasms.
Leukemia - 1 Sept 2025
Zhang Wenjun, Li Bing, Liu Jinqin, Yan Yiru, Yang Lin, Qin Tiejun, Xu Zefeng, Sun Qi, Jia Yujiao, Wang Huijun, Huang Gang, Wang Hongtao, Shi Lihong, Zhou Jiaxi, Xiao Zhijian
Abstract excerpt
U2AF1 mutations are common in patients with myelodysplastic neoplasms (MDS), suggesting that aberrant splicing of pre-mRNAs driven by mutant U2AF1 could play a critical role in MDS pathogenesis. Previous studies have demonstrated that U2AF1S34F mutation impairs the differentiation of erythrocytes and granulocytes, but the impact on megakaryocytes (MKs) remains unclear. Here, by integrating data from MDS patients...
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