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Article

PRKCH regulates hematopoietic stem cell function and predicts poor prognosis in acute myeloid leukemia.

Experimental hematology - 1 Sept 2017

Porter Shaina N, Magee Jeffrey A

Abstract excerpt

Acute myeloid leukemia (AML) cells often co-opt normal hematopoietic stem cell (HSC) programs to drive neoplastic proliferation, and HSC-related gene expression signatures have been identified as biomarkers for poor prognosis in AML patients. We sought to identify new regulators of HSCs and AML cells from previously published HSC and leukemia stem cell (LSC) gene expression signatures. We identified PRKCH...

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Topics

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Share to Core Binding Factor Alpha 2 Subunit
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Mice, Inbred C57BL

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Source

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Identifiers

PMID: 28596089
DOI: 10.1016/j.exphem.2017.05.006
PMCID: PMC6731097

Genes

PRKCH
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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