Article

The role of the fetal microenvironment in abnormal fetal haematopoiesis in Down syndrome

2015-01-01

Abstract excerpt

Children with Down syndrome (DS; trisomy 21, T21) have a 500-fold risk of developing acute megakaryoblastic leukaemia (AMKL) in early childhood compared to children without DS. DS-AMKL is preceded by a transient neonatal leukaemia, unique to DS, caused by acquired mutations in the GATA1 gene in fetal liver (FL) haematopoietic stem/progenitor cells (HSPC). Previous work has shown that T21 itself perturbs FL haemato...

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Literature Corpus work: ebbbd571-52c2-5fb5-9c26-d9f1f293bd26
DOI: 10.25560/29169

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