Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased risk of leukaemia in children with Down syndrome: a somatic evolutionary view

1 Jan 2021

Abstract excerpt

Children show a higher incidence of leukaemia compared with young adolescents, yet their cells are less damaged because of their young age. Children with Down syndrome (DS) have an even higher risk of developing leukaemia during the first years of life. The presence of a constitutive trisomy of chromosome 21 (T21) in DS acts as a genetic driver for leukaemia development, however, additional oncogenic mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genomic variations and chromosomal abnormalities
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33902785
DOI: 10.1017/erm.2021.6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased risk of leukaemia in children with Down syndrome: a somatic evolutionary viewPMID 33902785Read ↗

Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesisSemantic proximity Read ↗

The fetal pathogenesis of Down syndrome-associated leukaemiasSemantic proximity Read ↗

Haematopoietic development and leukaemia in <scp>D</scp>own syndromeSemantic proximity Read ↗

Tumorigenesis in Down's syndrome: big lessons from a small chromosome.Semantic proximity Read ↗

Down syndrome and leukemia: from basic mechanisms to clinical advancesSemantic proximity Read ↗

Down syndrome-associated leukaemias: current evidence and challengesSemantic proximity Read ↗

Evolution of myeloid leukemia in children with Down syndrome.Semantic proximity Read ↗

[Occurrence of cancer in individuals with Down syndrome].Semantic proximity Read ↗

[Incidence of cancer in individuals with Down syndrome].Semantic proximity Read ↗

Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndromeSemantic proximity Read ↗

A tumor profile in Down syndromeSemantic proximity Read ↗

The natural history of transient abnormal myelopoiesis in neonates and children with Down syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.