Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell multi-omics map of human fetal blood in Down syndrome.

Nature - 1 Oct 2024

Marderstein Andrew R, De Zuani Marco, Moeller Rebecca, Bezney Jon, Padhi Evin M, Wong Shuo, Coorens Tim H H, Xie Yilin, Xue Haoliang, Montgomery Stephen B, Cvejic Ana

Abstract excerpt

Down syndrome predisposes individuals to haematological abnormalities, such as increased number of erythrocytes and leukaemia in a process that is initiated before birth and is not entirely understood1-3. Here, to understand dysregulated haematopoiesis in Down syndrome, we integrated single-cell transcriptomics of over 1.1 million cells with chromatin accessibility and spatial transcriptomics datasets using human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoiesis
Share to Blood Cell Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down Syndrome

Share to Fetal Blood

Share to Multiomics

Share to Single-Cell Analysis

Share to Trisomy

Source

Open in PubMed Open full text

Identifiers

PMID: 39322663
DOI: 10.1038/s41586-024-07946-4
PMCID: PMC11446839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell multi-omics map of human fetal blood in Down syndrome.PMID 39322663Read ↗

Single-cell multi-omics map of human foetal blood in Down’s SyndromeSemantic proximity Read ↗

The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesisSemantic proximity Read ↗

A single cell multi-omic analysis identifies molecular and gene-regulatory mechanisms dysregulated in the developing Down syndrome neocortexSemantic proximity Read ↗

Hematologic Neoplasms Associated with Down Syndrome: Cellular and Molecular Heterogeneity of the Diseases.Semantic proximity Read ↗

A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortexSemantic proximity Read ↗

Gene Expression Studies in Down Syndrome; What Do They Tell Us about Disease Phenotypes?Semantic proximity Read ↗

Low-pass whole genome bisulfite sequencing of neonatal dried blood spots identifies a role for RUNX1 in Down syndrome DNA methylation profilesSemantic proximity Read ↗

Mechanistic insights into Down syndrome comorbidities via convergent RNA-seq and TWAS signalsSemantic proximity Read ↗

Hematologic Neoplasms Associated with Down Syndrome: Cellular and Molecular Heterogeneity of the Diseases.Semantic proximity Read ↗

Deciphering Haplotype-level Chromosome Conformation Alteration in Down Syndrome by Haplotype-resolved Multi-omics Analysis.Semantic proximity Read ↗

Identification of a DNA methylation signature in blood cells from persons with Down SyndromeSemantic proximity Read ↗

Down syndrome-associated leukaemias: current evidence and challengesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.