Article

The fetal pathogenesis of Down syndrome-associated leukaemias

2011-01-01

Abstract excerpt

Children with Down syndrome (DS; trisomy 21) have markedly increased susceptibility to acute megakaryoblastic leukaemia (AMKL) and acute lymphoblastic leukaemia (ALL) which, at least for AMKL, have their origin in fetal life. My project aims to identify and characterise abnormalities in haematopoiesis in human fetal DS in order to understand how T21 leads to the increase in leukaemia susceptibility in DS. Since bo...

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Literature Corpus work: 72124e58-9aeb-51d1-be1c-ff18fc5a55f3
DOI: 10.25560/12670

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