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Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target

15 Jun 2023

Abstract excerpt

Uveal melanoma (UM) has a high risk to progress to metastatic disease with a median survival of 3.9 months after metastases detection, as metastatic UM responds poorly to conventional and targeted chemotherapy and is largely refractory to immunotherapy. Here, we present a patient-derived zebrafish UM xenograft model mimicking metastatic UM. Cells isolated from Xmm66 spheroids derived from metastatic UM patient...

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Share to Epigenetics and DNA Methylation
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PMID: 37321991
DOI: 10.1038/s41420-023-01446-6

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