Article

LSD1 is a targetable vulnerability in gastric cancer harboring TP53 frameshift mutations

2024-11-20

Abstract excerpt

<title>Abstract</title> <p>Background TP53 mutations are linked to aggressive progression and chemoresistance in gastric cancer (GC). Frameshift mutation is the second most common mutation type of TP53. However, the consequences of this mutation type in GC were not well understood, and targeted therapies for cancer patients harboring frameshift mutations were also not established. Histone methylation significant...

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Literature Corpus work: eba2258b-0a92-5129-b728-40935395888d
DOI: 10.21203/rs.3.rs-5315632/v1

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