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Article

Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells.

Cancer research - 15 Mar 2011

Liu Yong-Yu, Patwardhan Gauri A, Bhinge Kaustubh, Gupta Vineet, Gu Xin, Jazwinski S Michal

Abstract excerpt

Tumor suppressor p53 plays an essential role in protecting cells from malignant transformation by inducing cell-cycle arrest and apoptosis. Mutant p53 that is detected in more than 50% of cases of cancers loses its role in suppression of tumors but gains in oncogenic function. Strategies to convert mutant p53 into wild-type p53 have been suggested for cancer prevention and treatment, but they face a variety of...

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Identifiers

PMID: 21278235
DOI: 10.1158/0008-5472.CAN-10-3107
PMCID: PMC3059346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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