Article
Differences in Gender and Overall Survival for Temperature-Sensitive TP53 Mutations in Gastroesophageal Cancer.
Medicina (Kaunas, Lithuania) - 20 Nov 2024
Shaikh Danial H, Park Margaret, Chen Jiandong, Huang Jeffrey, Friedman Mark S, Dam Aamir N, Luthra Anjuli K, Cappelle Saraswathi, Pena Luis R, Permuth Jennifer B, Mok Shaffer R S
Abstract excerpt
Background and Objectives: Temperature-sensitive (TS) mutants of TP53 are thermally unstable, unfolded, and inactive at body temperature but can be refolded and reactivated at sub-physiological temperatures. TS TP53 may be amenable for functional rescue by hypothermia or structure-stabilizing drugs, and may retain low-level transcriptional activity at 37 °C. TP53 mutations are observed in 47% of all esophageal...
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