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PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression

17 Sept 2013

Abstract excerpt

BACKGROUND: The TP53 pathway is frequently inactivated in human cancers. PICT1 (also known as GLTSCR2) is a novel regulator of the MDM2-TP53 pathway via its interaction with the ribosomal protein RPL11 in the nucleolus. However, the clinical significance of PICT1 in gastric cancer remains unknown. METHODS: To evaluate PICT1 function, we used shRNA to inhibit PICT1 expression in gastric cancer cells that expressed...

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PMID: 24045667
DOI: 10.1038/bjc.2013.561

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