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Article

S100A4 interacts with mutant p53 and affects gastric cancer MKN1 cell autophagy and differentiation.

International journal of oncology - 1 Dec 2015

Shen Wei, Chen Danqi, Liu Shanshan, Chen Lisha, Yu Aiwen, Fu Hao, Sun Xiuju

Abstract excerpt

The acquired p53 mutations are the most common genetic alterations in human cancers. Mutant p53 proteins tend to accumulate, augmenting their oncogenic potential. However, the mechanisms for mutant p53 accumulation are not known. Previous studies have shown that S100A4 interacts with wild‑type p53. The present study marks the first time the effect of S100A4 on mutant p53 levels in gastric cancer MKN1 cells, which...

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Identifiers

PMID: 26497012
DOI: 10.3892/ijo.2015.3209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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