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Article

Methylation of SLFN11 promotes gastric cancer growth and increases gastric cancer cell resistance to cisplatin

1 Jan 2019

Abstract excerpt

Background and Aim: Human SLFN11 gene encodes a protein with structural similarity to RNA helicases, which was reported to sensitize cancer cells to DNA-damaging agents. This study explored the epigenetic regulation and mechanism of SLFN11 in human gastric cancer. Methods: Eight human gastric cancer cell lines and 201 cases of primary gastric cancer were analyzed. Methylation specific PCR, flow cytometry,...

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Share to Epigenetics and DNA Methylation
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Identifiers

PMID: 31762822
DOI: 10.7150/jca.32511

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