Article

Yes1-mediated Cul9 phosphorylation promotes the metabolic reprogramming in gastric cancer

2023-10-20

Abstract excerpt

Although Cul9 has been implicated in human carcinogenesis, its upstream regulators and roles remain unknown. Herein, we indicate that the Cul9 promoter is hypermethylated in GCs. Bioinformatics, mass spectrometry, and unbiased-kinase screen identify the tyrosine kinase Yes1 as a key regulator of Cul9. Yes1 phosphorylates Cul9 at Y1505, promoting its selective autophagy. Patient-associated mutation of Yes1 or helic...

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Literature Corpus work: e58927f3-048d-5be0-b437-b8a75caa9b3e
DOI: 10.1101/2023.10.18.562906

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