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Article

Specific regulation of BACH1 by the hotspot mutant p53R175H reveals a distinct gain-of-function mechanism.

Nature cancer - 1 Apr 2023

Su Zhenyi, Kon Ning, Yi Jingjie, Zhao Haiqing, Zhang Wanwei, Tang Qiaosi, Li Huan, Kobayashi Hiroki, Li Zhiming, Duan Shoufu, Liu Yanqing, Olive Kenneth P, Zhang Zhiguo, Honig Barry, Manfredi James J, Rustgi Anil K, Gu Wei

Abstract excerpt

Although the gain of function (GOF) of p53 mutants is well recognized, it remains unclear whether different p53 mutants share the same cofactors to induce GOFs. In a proteomic screen, we identified BACH1 as a cellular factor that recognizes the p53 DNA-binding domain depending on its mutation status. BACH1 strongly interacts with p53R175H but fails to effectively bind wild-type p53 or other hotspot mutants in...

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Identifiers

PMID: 36973430
DOI: 10.1038/s43018-023-00532-z
PMCID: PMC10320414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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