Article
Mutational spectrum of TP53 gene correlates with nivolumab treatment efficacy in advanced gastric cancer (TP53MUT study).
British journal of cancer - 1 Oct 2023
Ando Koji, Nakamura Yoshiaki, Kitao Hiroyuki, Shimokawa Mototsugu, Kotani Daisuke, Bando Hideaki, Nishina Tomohiro, Yamada Takanobu, Yuki Satoshi, Narita Yukiya, Hara Hiroki, Ohta Takashi, Esaki Taito, Hamamoto Yasuo, Kato Ken, Yamamoto Yoshiyuki, Minashi Keiko, Ohtsubo Koushiro, Izawa Naoki, Kawakami Hisato, Kato Takeshi, Satoh Taroh, Okano Naohiro, Tsuji Akihito, Yamazaki Kentaro, Yoshino Takayuki, Maehara Yoshihiko, Oki Eiji
Abstract excerpt
BACKGROUND: Although nivolumab has a high efficacy, reliable biomarkers are needed to predict the efficacy. We evaluated the nivolumab efficacy according to the TP53 mutation in advanced gastric cancer patients enrolled in the GI-SCREEN project. METHODS: Sequence data of tumour specimens and clinicopathological information of 913 patients with advanced gastric cancer who were enrolled between April 2015 and March...
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